My PhD work on non-canonical viral translation mechanisms.
Summary Programmed –1 ribosomal frameshifting (-1FS) and stop codon readthrough are used by many RNA viruses and retroviruses to permit the regulated expression of multiple proteins from a single transcript. This dissertation investigated the biological role of readthrough in the model gammaretrovirus murine leukaemia virus (MuLV) and investigated frameshifting at the coronavirus infectious bronchitis virus (IBV) -1FS signal.
Translational readthrough—suppression of termination at a stop codon—is exploited in the replication cycles of several viruses and represents a potential target for antiviral intervention. In the gammaretroviruses, typified by Moloney murine leukemia …